Pharyngoesophageal diverticulum, also known as Zenker's diverticulum (ZD), is an acquired disease that is formed by the outpouching of hypopharyngeal mucosa between the inferior pharyngeal constrictor muscle and the cricopharyngeal muscle in an area of junctional muscle weakness known as Killian's triangle. Its pathophysiology is not well known but is thought to be incoordination between pharyngeal contraction and upper esophageal sphincter relaxation. Evidence also suggests that during swallowing, high hypopharyngeal pressures occur in some people because of poor compliance of the upper esophageal sphincter. X 1 Veenker, E.A., Andersen, P.E., and Cohen, J.I. Cricopharyngeal Spasm and Zenker's diverticulum.
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